Endocrine Abstracts

Glucocorticoids (GCs) have an important role in inflammation, apoptosis and immunosuppression and are among the most widely prescribed medications in clinical practice. GCs exert their effect by binding to the transcription factor, glucocorticoid receptor (GR). GCs are used in the treatment of acute lymphoblastic leukaemia (ALL) as they induce apoptosis in lymphoid cells, however resistance and side effects still occur frequently. Computational modeling has enormous potential ...